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These prebiotics reshape the profile of circulating inflammatory mediators, leading to a significant reduction in pro-inflammatory cytokinesincluding TNF-, IL-6, IL-8, and IL-1within both plasma and BALF 176

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All animals were treated humanely, and all studies were carried out in accordance with good laboratory practice (GLP) (China Food and Drug Administration, CFDA) guidelines for nonclinical laboratory studies of drugs issued by the National Scientific and Technological Committee of the Peoples Republic of China