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This approach was further applied to modification of GSH, where modification with 4-bromo-1-butene, followed by TEC afforded glycosylated GSH with 97% yield

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Visible improvements in skin brightness and texture may be noticed within 2-3 months of regular use

Moreover, since the inception of this study, multiple metabolic mechanisms promoting drug resistance have been suggested for 5FU treatment, including changes in amino acid metabolism 69,70 , serine and glycine metabolism 71,72,73 and glycolysis 74,75 , corroborated within our study and independently validating our findings