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Some people use glutathione supplements for skin lightening purposes, although its effectiveness for this purpose is a topic of debate among experts

Reviewers have repeatedly noted the need for randomized controlled trials before any therapeutic claim can be supported [12]

Oral tranexamic acid: Multiple studies demonstrate that low-dose oral tranexamic acid can significantly reduce melasma severity by inhibiting the vascular and inflammatory pathways that activate melanocytes

Levobupivacaine, distinct from its anesthetic effect, inhibits SLC7A11/GPX4 and promotes p53-mediated ferroptosis to exert an antitumor effect in non-small cell lung cancer (Meng et al., 2021)