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Remember, MTHFR is critical for the formation of 5-Me-THF (aka, L-methylfolate, L-methyl-THF) which is involved in the methylation of homocysteine and its conversion to methionine

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Despite unchanged ILC2 numbers, melatonin significantly reduced BALF IL-5 and IL-13 levels ( Figures 1M, N ), suggesting functional suppression of type 2 cytokine production rather than depletion of ILC2s ( Figures 1K, L )

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