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For example, when the environmental conditions change, and the intestinal permeability increases (leaky gut), systemic translocation of a part of GM, which is LPS, directly activates the TLR4 receptor

The slower gastric emptying adds another layer

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In conclusion, phytosterols and alkaloids can disrupt cancer-associated inflammatory and immune escape mechanisms by inhibiting tumor pro-inflammatory responses and enhancing antitumor immune effects, demonstrating potential clinical applications in improving the tumor microenvironment