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NMDA receptors requirement for coincidence detection to activate and ability to flux calcium ions makes the NMDA receptor integral to synaptic plasticity, and NO co-transmission is intimately coupled to NMDA receptor activity in this context (Hansen et al., 2017)

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View on PubMed Involvement of the AT1 Receptor in Effects of Angiotensin IV and LVV-Haemorphin 7 on Hippocampal Memory Demonstrated that angiotensin IV analogs (the parent class of Dihexa) improve hippocampal memory performance in rodents, supporting the AT4/IRAP receptor pathway as a target for cognitive enhancement (J Neurochem, 2010)

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