Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective
Skin Brightening:** Kojic acid, derived from fungi, helps helps to visibly reduce the appearance of uneven tone, promoting a brighter complexion
Novo Nordisk's FY2024 results confirmed the structural nature of the GLP-1 demand wave: total revenues grew 26% to DKK 290.4 billion (approximately USD 41 billion), with Obesity care revenues up 56% to DKK 65.1 billion (approximately USD 8.2 billion)
NET and NETosis are involved in the pathological process of autoimmune diseases such as RA