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Third, cosmetic-study endpoints (subjective firmness scores, instrumental elasticity, photographic grading) are softer and more variable than the hard clinical endpoints used in drug trials

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Lower-than-average serum BDNF is associated with cognitive impairment severity, and decreasing levels correlate with advancing Alzheimer disease

These prodrugs remain intact and inactive when circulating in plasma, that is, add profragments preferentially cut by enzymes enriched in the tumor (such as histone deacetylase (HDAC) or cathepsin), and then selectively release DON in the target tissue, thereby reducing the dose and increasing the therapeutic index