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Two possible mechanisms of NO-mediated protein S-glutathionylation can be envisioned: through a GSNO (activated thiol) formation and its consequent reaction with protein-thiol (179) or through an intermediate protein-thiol nitrosylation (activated protein-thiol: analog of sulfenic acid) and its consequent reaction with GSH

The highest efficacy dose from Phase 2, producing up to 24.2% average weight loss at 48 weeks

The ability of atypical antipsychotic drugs vs

The induction and intensification of cell death, along with barriers to macrophage clearance and absorption of dead cells, increase the exposure of intracellular contents to the immune system, triggering an immune response