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Potential Risks of Taking Semaglutide and Tirzepatide Together Because both medications influence digestion and metabolism, combining them may increase the risk of certain side effects

Gallbladder events : As with other incretin-based therapies, there is a potential risk of gallbladder disease, including cholelithiasis (gallstones)

However, overall body weight was still reduced by 5.0% to 9.8% at the end of week 32 in the groups administered cagrilintide and by 7.2% at the end of week 32 in the group administered liraglutide [1]