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Results Increased expression of antioxidant enzymes in mice that overexpress human -synuclein Using two existing transgenic mouse lines, we produced a new mouse, SARE, which overexpresses human -synuclein under the direction of the TH promoter and is capable of reporting an antioxidant response via expression of human placental alkaline phosphatase (hPLAP)

The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting

Smokers are also more likely to need dialysis or kidney transplants

It has been reported that neutrophils in the peripheral blood and synovial fluid of RA patients can promote ROS generation