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Key genes promoting ROS/RNS production: Thbs1 , S100a8 and Nos2 , were significantly downregulated, while the glutathione S-transferase gene Gsta2 , involved in cellular anti-oxidative defence, was upregulated 36,37

NO pathway research can include: NOS activity eNOS signalling NO release markers vascular relaxation response oxidative stress balance endothelial cell function angiogenesis response This makes the NO system a useful bridge between gastrointestinal, vascular and soft tissue studies