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it's about understanding the why

Mechanistically, the microbiota transplant reduced lipopolysaccharide (LPS) levels in the colon, the serum, and the substantia nigra (SN) of the midbrain, suppressing the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor kappa B (NF-B) signaling pathway and its downstream pro-inflammatory products in both the SN and the colon (Zhao et al., 2021)

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There is also a specific biological reason the systemic route attracted attention