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Nanotechnology enables the design of nanoscale materials with unique physicochemical properties, including high surface area, tunable surface chemistry, and enhanced reactivity

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Electronic cigarettes have a major role in HNSCC which has to be made evident in coming years due to its high usage [55]

As mentioned above, TFCs express toll-like receptors, which induce the activation of the innate immune system by responding to the PAMPs and damage-associated molecular patterns (DAMPs) on the surface of microorganisms, making lymphocytes product multiple proinflammatory cytokines, such as IL-1, IL-18, IFN-, and TNF- [186]