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Bioconjug Chem

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The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45

Further, animals were sacrificed to isolate the hippocampus as well as remaining parts of the brain to perform subsequent biochemical and histopathological studies (Figure 1)