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Consideration in the design of effective nano herbal formulation of novel phytoconstituents comprises understanding the cell signaling pathway in the origin and progress of CKD, followed by its inhibition in altering the disease condition (inflammation, oxidative stress, and fibrosis)

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In summary, liver enlargement can be the consequence of hepatocellular hypertrophy, hepatocellular hyperplasia, or both in response to enzyme induction