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NAD+ helps produce NADPH (the energy that keeps Glutathione active), while Glutathione helps reduce oxidative stress, which protects and preserves NAD+

[6] [7] It's worth noting that the body can store vitamin B12 in the liver for several years, which provides some protection against short-term dietary inadequacy

4 Other trials on NAD+ for addiction typically had patients use 500-1000mg of NAD+ in 300mL of normal saline typically with a loading period of daily dosing for four days, followed by a taper period of twice weekly dosing for a month, and finally reducing to just twice monthly dosing until resolution of addiction

10.1002/hbm.20708 Hum