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Although many clinical trials have reported that vitamins C and E have beneficial effects on alleviating the symptoms of oxidative stress-related diseases such as cardiovascular diseases and cancers, the same number of studies have reported no or very limited effects of supplemental vitamins C and E

NAC is a precursor to glutathione, meaning your body uses it to build the "master antioxidant." Some people prefer a "top-down" approach (taking glutathione directly) while others prefer a "bottom-up" approach (taking precursors)

Miyawaki K, Yamada Y, Ban N et al (2002) Inhibition of gastric inhibitory polypeptide signaling prevents obesity

& Gibson, R