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A disturbance in microbiota composition has been demonstrated to result in heightened levels of uremic toxins, including IS, PCS, and TMAO, along with a decline in LPS and beneficial short-chain fatty acids

Do not skip doses or stop giving the medication without consulting your veterinarian

Moreover, factors such as fluid dynamics, pH, and disease-induced pathological alterations in the brains microenvironment (i.e., changes in enzymatic activity, impairment in vascular function, and inflammation) can significantly influence drug distribution and efficacy (Nance et al., 2022)

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