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This estimand will be analysed in participants who undergo follow-up RBANS assessment at 180 days (+0, 10 days) and who have taken at least 80% of the study medication (principal stratum strategy) Secondary estimand safety 1

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Front Physiol 8:19 Gupta A, Vij G, Sharma S et al (2009) Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model