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This is not a speculative concern it is precisely why parenteral nutrition copper dosing is an order of magnitude lower than oral intake, at 0.30.5 mg/day, and why the dose is reduced, with monitoring of serum concentrations, in cholestasis where biliary excretion is impaired

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Nonetheless, because autism is influenced by multiple interacting genetic and environmental factors that are case-specific and inherent limitations in post-mortem brain, these observations will require confirmation in subsequent studies