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In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of sodium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph compatible (i.e

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Subsequently, glutamate provides a substrate for the synthesis of -ketoglutarate, the key metabolite of the TCA cycle (9)

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