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They can reduce levels of Bcl-2 and increase levels of Bax and caspase-3, two proteins that promote cell death, and trigger mitochondrial mediated apoptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Kamga C.K., Zhang S.X., Wang Y

At a glance Drug / evolocumab (Repatha), a PCSK9-inhibitor biologic antibody Supplement / glutathione (oral, liposomal, or IV forms) Known interaction / none documented in published literature or FDA label Interaction type / not applicable, no shared metabolic pathway identified Evolocumab clearance / proteolytic catabolism, not CYP450 or GSH-dependent Glutathione CYP effect / negligible at typical oral doses (250 to 1,000 mg/day) LDL-C reduction with evolocumab / up to 59% vs

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