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Most patients respond to a short course of antibiotics (often ciprofloxacin or metronidazole), although some patients have a prompt recurrence after discontinuation of antibiotic therapy (termed antibiotic- dependent chronic pouchitis)

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The standard recommendation is one 500 mcg capsule twice daily on an empty stomach

The peptide backbone itself is small and, like other short peptides, is subject to degradation by plasma and tissue peptidases, giving it a short intrinsic half-life