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10.1097/GCO.0000000000000708 25 HonardoustP.NajafpourA.MohammadiR

Twenty four hours after hypoxia-exposure of the neuronal cultures, the classic microglial proinflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF and interleukin-1- (IL-1), are upregulated only in response to mild neuronal injuries, while the trophic microglial effector BDNF is upregulated in response to the degrees of neuronal ischemia injuries (57,58)