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Cagrilintide-induced nausea results from its dual-receptor mechanism: it activates amylin receptors in the area postrema (the brain's chemoreceptor trigger zone for nausea signalling) while simultaneously slowing gastric emptying by up to 70%

The approval demonstrates the potential of Fasenra to help patients suffering from eosinophilic disease beyond severe asthma, Ruud Dobber, executive vice president of AstraZenecas biopharma business unit, said in a statement

Routine aspiration is no longer recommended by the WHO or CDC for the deltoid, ventrogluteal or vastus lateralis sites, as those sites carry negligible vessel risk

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