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With the smallest effect size was calculated as 1.60 at o -toluidine within 15 BoE, a sample size of 12 subjects in each study group was considered sufficient to attain 80% power to show a reduction of 40% in 15 BoE in the five study groups (four heated tobacco products and SS) compared with the CC group using two-sided tests with 5% alpha level (Bonferroni-correction, = 0.05/5)

In conclusion, people should stop this malpractice and teach others to engage in positive health behaviors

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