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Well Differentiated Neuroendocrine Carcinoma (Typical Carcinoid) with Mediastinal Lymph Node Metastases: Surgical Outcomes and Whole Exome Sequencing (WES)

Statements Author contributions XF, NL and XL made data analysis

In OA models induced by interleukin-1 beta (IL-1) and ferric ammonium citrate (FAC), hallmark ferroptosis markers such as glutathione peroxidase 4 (GPX4) and solute carrier family seven member 11 (SLC7A11) exhibit significant downregulation, whereas expression levels of the tumor suppressor gene p53 and acyl-CoA synthetase long-chain family member 4 (ACSL4) are elevated (Yao et al., 2021)

Notably, this approach avoids the risks associated with immunosuppression, such as increased infection rates or tumor formation, as confirmed by long-term follow-up studies conducted up to four years post-treatment