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In fact, many studies on natural products as potential therapy approaches against APAP hepatotoxicity were due to their enhancement effects on phase II metabolic enzymes and/or inhibitory effects on cytochrome P450 enzymes [125], [130], [17],]

This indicates that felinine production downregulates cholesterol biosynthesis, as the in vivo synthesis of cholesterol is affected by cholesterol intake, resulting that Tsushima leopard cats may use more isopentenyl diphosphate for the cholesterol biosynthesis rather than felinine production in winter season as compared to Iriomote cats

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10.1007/s12035-014-8856-9 15 CornelisP.WeiQ.AndrewsS