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Abbreviations PCA: Principal component analysis DEGs: Differentially expressed genes GO: Gene ontolog KEGG: Kyoto Encyclopedia of Genes and Genomes PPI: Protein-protein interaction TF: Transcription factor TSNA: Tobacco-specific nitrosamine MF: Molecular function CC: Cellular component BP: Biological process FC: Fold change NNN: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone NAT: (R,S)-N-nitrosoanatabine NAB: (R,S)-N-nitrosoanabasine NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone References Giuseppe D, Pamela M