FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)
As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted
Some pursue B12 injections for energy during busy seasons or travel
It concurrently impairs antioxidant defenses (e.g., by inhibiting catalase) [32] and promotes inflammation by elevating pro-inflammatory cytokine levels and reducing nitric oxide (NO) bioavailability [33]