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Description

Dermal lymphatic dilation in a mouse model of alopecia areata

It is naturally synthesized by every cell in the body, with particularly elevated concentrations found in the liver

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Nitrofurantoin is a prodrug that is activated by cellular nitroreductases leading to the formation of reactive species that damage cellular macromolecules, most prominently DNA, causing nucleoid relaxation and, at high doses, destruction of the entire nucleoid