The clinical evidence, however, is almost entirely topical and cosmetic , and it is more mixed than the marketing suggests
For instance, Selenium supplementation and selenoproteins enhance GPX4 activity, boost lipid peroxide scavenging, and increase selenoproteins, reducing lipid peroxidation (Ingold et al., 2018
Biomarker Assessment: Who May Benefit Most from Glutathione Support Individuals with documented oxidative stress markerssuch as elevated malondialdehyde (MDA), reduced superoxide dismutase (SOD), or low plasma glutathionemay represent candidates for glutathione supplementation
Biol Trace Elem Res 160(2):169175 Seo JA, Song SW, Han K, Lee KJ, Kim HN (2014) The associations between serum zinc levels and metabolic syndrome in the Korean population: findings from the 2010 Korean National Health and Nutrition Examination Survey