It can raise blood levels of creatinine (a waste product with a similar name), which can make it look like kidney function is worse, even if its not causing damage
BMC Biotechnol 15:84 Savoca MP, Tonoli E, Atobatele AG, Verderio EAM (2018) Biocatalysis by transglutaminases: a review of biotechnological applications
Cristae are the home of ETC complexes and changes in the structure would alter the distribution of mitochondrial complexes, thus influencing the efficiency of OXPHOS (Gilkerson et al., 2003
For example, the main clinical manifestation of OSF is a burning sensation and intolerance to spices, and as the disease progresses, patients experience reduction in mouth opening, which not only causes pain, poor oral hygiene and impaired chewing and swallowing, but also affects patients speaking and appearance, causing psychological issues and limitations in social activities (Wang et al., 2022)