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In animal models, oral BPC-157 reduced gut-ulcer lesions by up to 60% and accelerated tendon healing within two weeks

Despite the development of next-generation analogs with improved pharmacological properties, clinical translation is constrained by a narrow therapeutic window due to on-target and off-target toxicities

The Q-SYMBIO study, a randomised controlled trial with 420 participants, demonstrated that CoQ10 supplementation (100 mg three times daily) reduced cardiovascular mortality in patients with moderate to severe heart failure

While directly measuring neuroprotection in living patients is technically unfeasible, alternative strategies, such as monitoring pro-inflammatory markers or neuroprotective cytokines in the plasma of patients receiving istradefylline, could offer valuable mechanistic insights and serve as surrogate indicators of therapeutic activity [485]