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For very high disease activity, you may even go right to an IL-17 blocker and bypass anti-TNFs, which have not proven as effective for ankylosing spondylitis as they have been for other types of inflammatory arthritis
If you are losing hair and want a reliable, independently maintained overview of the recognised causes and treatments, the NHS hair loss pages are a good starting point
If constipation resolves at the lower dose, you've identified your tolerance threshold
