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These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function

Post-Exertional Malaise (PEM) and Fatigue: Alpha lipoic acid and sulforaphane help protect the mitochondrial electron transport chain from superoxide radical damage, supporting more efficient ATP (energy) production and potentially raising the threshold for exertion-induced crashes

[5] These two classes of TrxR have only ~20% sequence identity in the section of primary sequence where they can be reliably aligned

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