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Toutefois, comme les deux premiers ECR ont utilis la modification de la frquence au fil du temps, la frquence dadministration peut tre rduite avec une surveillance si les niveaux sont normaux et stables

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Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code