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Comment The intracytoplasmic inclusion of large numbers of erythrocytes in hepatocytes has been seen exclusively in mice (Harada et al

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In contrast to large scale GWAS which have not established an association between CLOCK genes and bipolar disorder, smaller linkage studies, while lacking adequate replication, have noted an association between several circadian genes, including TIMELESS, ARNTL1, PER3, NR1D1, CLOCK, and GSK-3 beta, and the bipolar illness (181, 182, 186)