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Research has found a link between low vitamin B12 levels and depression, and there are several mechanisms by which this vitamin may influence mental well-being: It is involved in the production of "feel-good" hormones such as serotonin and dopamine, which greatly influence mood

Low levels of glutathione send messages to trigger apoptosis or cell death

It would also be pertinent to add laboratory assays that allow putting the results in the larger context of cellular senescence, which seems to be disturbed in several disorders where fatigue has been associated with mitochondrial dysfunction

Genome-Wide Significant Predictors of Metabolites in the One-Carbon Metabolism Pathway. Human Molecular Genetics, vol