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The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)

Adequate GSH maintains GPX4 in its reduced state, preventing oxidative inactivation, whereas GSH depletion leads to decreased GPX4 activity or even complete inactivation

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Increased granulosa cell apoptosis is a primary reason for diminished ovarian function, resulting in accelerated follicular atresia and increased oocyte apoptosis [36, 37]