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250 These mice exhibit impaired axonal mitochondrial membrane potential and bioenergetic function, indicating a lack of reserve capacity

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In the United States, such products are categorized as dietary supplements and are not subject to the same rigorous validation of efficacy as drugs, with regulation focusing on safety rather than efficacy

By contrast, muscle biopsies from GH deficient adults after GH treatment have revealed increased glucose but low-normal glucose-6-phosphate levels (103)