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Studies analyzing Meibomian gland probing (MGP) focusing on the procedures safety and efficacy have been conducted in the United States, Mexico, China, Russia, Cuba, Turkey, India, and Japan with peer reviewed articles having been published supporting the effectiveness of MGP for patients refractory to standard care as a first-line treatment for Meibomian gland dysfunction

The peptide has also been studied for its effects on circadian gene expression and neuroendocrine rhythms