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A., Tanner, J
Abbreviations AAS: Atomic absorption spectroscopy AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis Atox1, CCS, HAH1, COX17: Copper chaperones ATP7A, ATP7B, Cu-ATPases: Copper-transporting P-type ATPases A: Amyloid beta CNS: Central nervous system CopC: Bacterial peripasmic copper binding proteins COX, mitochondrial complex IV: Cytochrome c oxidase (EC 1.9.3.1) CP: Choroid plexus Ctr1, Ctr2: Copper(I) transporters CTZ: cuprizone (bis-cyclohexanoneoxalyl-dihydrazone) Cu, Zn-SOD1: Copper, zinc superoxide dismutase CuAO: Copper aminooxidase CWD: Chronic wasting disease DMT1: Divalent metal transporter D-pen: D -penicillamine EM: Electron microscopy FAAS: Flameless atomic absorption spectroscopy GABA: Gamma-aminobutyric acid GHK: SPARC fragment Gly-His-Lys GSH: Gluthation (gamma-L-glutamyl-L-cysteinylglycine) GSSG:: Gluthation disulfide HC: Huntingtons chorea Htt: Huntingtin protein ICC: Indian childhood cirrhosis ICP-AES: Inductively coupled plasma - atomic emission spectrometry IPs: Inositol phosphates Kir4.1: Inwardly rectifying K + ion channel 4.1
A transcriptome analysis of CGCs revealed that the genes that differed between mature and immature CGCs were mostly involved in steroid metabolism, inflammation, apoptosis, cell cycle regulation, and extracellular matrix remodeling (97)
Scientists also investigate how these compounds interact with signaling systems linked to metabolic performance and energy regulation
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