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Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

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Cancer risk among patients with multiple sclerosis and their parents

This therapy obviously needs to be more investigated to avoid side effects in normal tissues but the combination of specific senescence markers to cytotoxic drugs is a potential promising therapy