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When you activate this receptor too aggressively, nausea, vomiting, and diarrhea become significant problems

sometimes mild right upper quadrant discomfort, hepatomegaly, acanthosis nigricans, or cryptogenic cirrhosis Often associated with features of metabolic syndrome: type 2 diabetes, obesity, dyslipidemia (hypertriglyceridemia, low HDL cholesterol, hypobetalipoproteinemia), and cardiovascular disease Increased AST and ALT levels (usually 2.0 Acute decompensated Wilson disease Anhepatic Primary nonfunction of allograft within 7 d of transplant Hepatic artery thrombosis within 7 d of transplant Cirrhosis from any cause MELD-Na score, calculated MELD-Na score exceptions Hepatocellular carcinoma Perihilar cholangiocarcinoma Hepatopulmonary syndrome Portopulmonary hypertension Primary hyperoxaluria Familial amyloid polyneuropathy Cystic fibrosis Metabolic disease (urea cycle disorder or organic acidemia) Hepatic artery thrombosis (within 14 d of transplant but does not meet criteria for status 1A) Appeal to regional review boarda Abbreviations: ICU, intensive care unit

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Goodman HM