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In the transcriptomics of Microsporum canis , there are 6 signaling pathways that have significant changes in Gene Ontology functional enrichment analysis after berberine treatment, including steroid biosynthesis, steroid hormone biosynthesis, Parkinsons disease, 2,4-Dichlorobenzoic acid (2,4-DCBA) degradation and biosynthesis of tropane, piperidine and isoquinoline alkaloids (Xiao et al., 2015)

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To sum up, some patients report the worsening of symptoms within the first few days or weeks when they begin B12 shots