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While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]

Int J Immunopathol Pharmacol 2019;33:2058738419828613

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Mortality Reduction: In long-term human observations (15 years), pineal peptide preparations were associated with a significant reduction in all-cause mortality