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In rats assessed 24 weeks after ischemic injury, minocycline improved perfusion, reduced BBB permeability with higher levels of TJ proteins, and decreased the frequency of proinflammatory microglia, shifting their activation to an M2-like, or anti-inflammatory, phenotype with upregulation of transforming growth factor beta (TGF- ) and IL-10 and decreased TNF- and IL-1 (Yang et al., 2015)

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In a study published in the journal PLoS One, researchers found that BPC 157 was effective in reducing inflammation and promoting healing in rats with Achilles tendon injuries (2)