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In cigarettes, there are also other additives that increase the likelihood of someone becoming addicted, but nicotine itself is addictive. Mark Rubinstein, professor of pediatrics at the University of California, San Francisco and lead author of the study Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes, found that e-cigarette vapor is unsafe due to its cancer-causing properties

34 Thus, further consideration for sex differences is required in studying the cross-tolerance of nicotine and alcohol reinforcement

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